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Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity
Chuanfeng Wu, Cynthia E. Dunbar
Frontiers of Medicine 2011, Volume 5, Issue 4, Pages 356-371 doi: 10.1007/s11684-011-0159-1
Keywords: gene therapy hematopoietic stem cells insertional mutagenesis genotoxicity induced pluripotent stem cell
Frontiers of Medicine 2022, Volume 16, Issue 6, Pages 827-858 doi: 10.1007/s11684-022-0948-8
Keywords: infertility stem cell therapy mesenchymal stem cells pluripotent stem cells
The regulatory sciences for stem cell-based medicinal products
Bao-Zhu Yuan,Junzhi Wang
Frontiers of Medicine 2014, Volume 8, Issue 2, Pages 190-200 doi: 10.1007/s11684-014-0323-5
Over the past few years, several new achievements have been made from stem cell studies, many of whichMoreover, some stem cell-based products have been approved for marketing by different national regulatoryHowever, many critical issues associated mainly with incomplete understanding of stem cell biology andcell regulatory sciences with a goal of promoting the steadfast growth of the well-regulated stem celltherapies abreast of evolvement of stem cell sciences and technologies.
Keywords: stem cell-based medicinal products (SCMPs) stem cell therapy (SCT) safety effectiveness standards guidelines
Autologous bone marrow stem cell transplantation for the treatment of ulcerative colitis complicated
Hang Xiang,Xiaomei Zhang,Chao Yang,Wenhuan Xu,Xin Ge,Rong Zhang,Ya Qiu,Wanjun Sun,Fan Li,Tianyuan Xiang,Haixu Chen,Zheng Wang,Qiang Zeng
Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 522-526 doi: 10.1007/s11684-016-0485-4
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with continuous or recurrent symptoms. A 42-year-old male patient with intermittent diarrhea accompanied by bloody mucopurulent stools was admitted to our hospital. The diagnosis of UC was confirmed by a combination of laboratory examination, colonoscopy, and histological assay. The patient developed herpes zoster in the hospital, which challenged traditional treatments. Therefore, we performed an autologous bone marrow cells to modulate the immune system with his permission. Autologous bone marrow mononuclear cells were collected and injected locally into the bowel mucosa, and subsequently injected systemically through a peripheral vein. After the patient underwent auto bone marrow mononuclear cells transplantations twice, the patient’s symptoms were alleviated. Furthermore, he recovered from hematochezia, and his hypersensitive C reactive protein decreased. Colonoscopy results showed reduced lesions and decreased areas with bleeding and edema in the sigmoid colon and rectum. No recurrence occurred in the subsequent two years, but long-time monitoring is still necessary for the prophylaxis of colorectal cancer.
Keywords: autograft bone marrow stem cells ulcerative colitis cell therapy
The unregulated commercialization of stem cell treatments: a global perspective
Douglas Sipp
Frontiers of Medicine 2011, Volume 5, Issue 4, Pages 348-355 doi: 10.1007/s11684-011-0150-x
Keywords: stem cell tourism medical ethics stem cell policy and regulation alternative medicine
Therapeutic potential of stem cell in liver regeneration
Jinzheng LI, Min LI, Bolin NIU, Jianping GONG
Frontiers of Medicine 2011, Volume 5, Issue 1, Pages 26-32 doi: 10.1007/s11684-011-0107-0
Keywords: stem cell liver disease regenerative medicine
Stem cell niches and endogenous electric fields in tissue repair
Li LI, Jianxin JIANG
Frontiers of Medicine 2011, Volume 5, Issue 1, Pages 40-44 doi: 10.1007/s11684-011-0108-z
Adult stem cells are responsible for homeostasis and repair of many tissues.Endogenous adult stem cells reside in certain regions of organs, known as the stem cell niche, whichMany regulatory factors are involved in the stem cell-based repair process, including stem cell nichesHere we briefly review the role of stem cell niches and endogenous electric fields in tissue repair,and hypothesize that endogenous electric fields become part of stem cell niche in the wound site.
Keywords: stem cell stem cell niche electric field tissue repair
Transcriptomics and proteomics in stem cell research
Hai Wang,Qian Zhang,Xiangdong Fang
Frontiers of Medicine 2014, Volume 8, Issue 4, Pages 433-444 doi: 10.1007/s11684-014-0336-0
Stem cells are capable of self-renewal and differentiation, and the processes regulating these eventsIn particular, the molecular mechanisms of the self-renewal, proliferation, and differentiation of stemcell biology.and proteomic characterization of the different stem cell processes.cell biology and promote the clinical applications of stem cells.
Keywords: embryonic stem cells transcriptomics proteomics
Xiaodong Mo, Xiaojun Huang
Frontiers of Medicine 2013, Volume 7, Issue 3, Pages 306-315 doi: 10.1007/s11684-013-0279-x
Allogeneic hematopoietic stem cell transplantation (HSCT) is one of the most effective options forSeveral protocols (with or without ex vivo T-cell depletion (TCD)) have been established worldwide
Keywords: partially matched related donor hematopoietic stem cell transplantation allogeneic
Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 227-239 doi: 10.1007/s11684-021-0896-8
Keywords: cannabidiol depression radial neural stem cells neurogenesis
In vivo imaging of hematopoietic stem cell development in the zebrafish
Panpan Zhang, Feng Liu
Frontiers of Medicine 2011, Volume 5, Issue 3, Pages 239-247 doi: 10.1007/s11684-011-0123-0
Keywords:
hematopoietic stem cell
hematopoiesis
Yuting Tan,Han Liu,Saijuan Chen
Frontiers of Medicine 2015, Volume 9, Issue 4, Pages 412-420 doi: 10.1007/s11684-015-0423-x
Keywords: preleukemic stem cell acute myeloid leukemia relapse DNMT3A
The stem cell and tissue engineering research in Chinese ophthalmology
GE Jian, LIU Jingbo
Frontiers of Medicine 2007, Volume 1, Issue 1, Pages 6-10 doi: 10.1007/s11684-007-0002-x
Keywords: available observable neuroregeneration protection function reconstruction
Dental stem cell and dental tissue regeneration
Qiming Zhai, Zhiwei Dong, Wei Wang, Bei Li, Yan Jin
Frontiers of Medicine 2019, Volume 13, Issue 2, Pages 152-159 doi: 10.1007/s11684-018-0628-x
Keywords: stem cells pulp regeneration periodontal regeneration
Yingchen Li,Guoheng Hu,Qilai Cheng
Frontiers of Medicine 2015, Volume 9, Issue 1, Pages 20-29 doi: 10.1007/s11684-014-0371-x
Keywords: cellular therapy transplantation human umbilical cord mesenchymal stem cells ischemic stroke
Title Author Date Type Operation
Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity
Chuanfeng Wu, Cynthia E. Dunbar
Journal Article
Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism
Journal Article
The regulatory sciences for stem cell-based medicinal products
Bao-Zhu Yuan,Junzhi Wang
Journal Article
Autologous bone marrow stem cell transplantation for the treatment of ulcerative colitis complicated
Hang Xiang,Xiaomei Zhang,Chao Yang,Wenhuan Xu,Xin Ge,Rong Zhang,Ya Qiu,Wanjun Sun,Fan Li,Tianyuan Xiang,Haixu Chen,Zheng Wang,Qiang Zeng
Journal Article
The unregulated commercialization of stem cell treatments: a global perspective
Douglas Sipp
Journal Article
Therapeutic potential of stem cell in liver regeneration
Jinzheng LI, Min LI, Bolin NIU, Jianping GONG
Journal Article
Stem cell niches and endogenous electric fields in tissue repair
Li LI, Jianxin JIANG
Journal Article
Transcriptomics and proteomics in stem cell research
Hai Wang,Qian Zhang,Xiangdong Fang
Journal Article
Advancement of human leukocyte antigen-partially matched related hematopoietic stem cell transplantation
Xiaodong Mo, Xiaojun Huang
Journal Article
Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation
Journal Article
In vivo imaging of hematopoietic stem cell development in the zebrafish
Panpan Zhang, Feng Liu
Journal Article
Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property
Yuting Tan,Han Liu,Saijuan Chen
Journal Article
The stem cell and tissue engineering research in Chinese ophthalmology
GE Jian, LIU Jingbo
Journal Article
Dental stem cell and dental tissue regeneration
Qiming Zhai, Zhiwei Dong, Wei Wang, Bei Li, Yan Jin
Journal Article